Ocupharm Diagnostics S.L

Experimentation
In-Vivo

For more than 10 years, we have been conducting experiments on a lagomorph model for the pharmaceutical and healthcare industries.
We provide a comprehensive system tailored to the customer’s needs.
The protocols are designed in conjunction with the client to meet their expectations and needs. We have the facilities, personnel, and necessary accreditations to carry out in-vivo model experimentation.

Biocompatibility

In accordance with Standard EN ISO 11979-5:2020. Verification of the potential compatibility or capacity for irritation in ocular tissues of products or materials used in pharmacology or medical devices

Irritation Test

Ocular and skin irritation test for ophthalmic products in an animal model

Kinetics and Pharmacokinetics

Determination of the qualities associated with the delivery and penetration of drugs and medical devices via the ophthalmic route, including those linked to medical devices or instillations. Generation of dose-response graphs, detection in target tissues, and access to systemic pathways

Impression Cytology

Sample collection, processing, analysis, and quantification of goblet cells in impression cytologies of conjunctival tissue. This helps evaluate the degree of dry eye. Sample collection is done using the EyePrim™ device

Healing

Determination of the wound-healing capacity of ophthalmic products designed for this purpose in corneal tissue. Assessing the cells’ ability to migrate and proliferate

Inflammation

Assessment of the capacity to reduce inflammation in ocular tissues by determining specific markers (IL-6, IL-8, and MMP9) using PCRrt techniques. Proteomic quantifications with ELISA kits for TNF-α, IL-6, IL-8, and MMP9

Dry Eye Model

Dry eye model in lagomorphs through the instillation of BAC (Benzalkonium Chloride)